The Team Rocket leader, Giovanni, has found Mewtwo in a remote area of the Johto region. As Giovanni tries to re-capture Mewtwo, Ash and his friends are kidnapped by Domino, a new Team Rocket member, while trying to rescue Pikachu from Jessie and James. The Clone Pokemon are also captured and are then used as bait for Mewtwo. The situation then becomes a battle between the wills of Mewtwo and Giovanni; and Mewtwo also tries to discover if it and the clones have a purpose in life, even though they are products of science. 
(Source: Anime News Network)

A team of scientists use the DNA of a rare Pokemon, Mew, to create the world's strongest Pokemon, Mewtwo. Not wanting to be used as an experiment, Mewtwo uses its psychic powers in a violent rage to destroy the scientists who created it. Mewtwo then tries to learn how to focus his powers with the aid of Giovanni, the man who funded the scientists' operations, but discovers that it is being used again. So Mewtwo decides to find its own purpose in life, and carry out its revenge on humans by destroying life on earth by using a deadly storm. Ash Ketchum and a group of other Pokemon Trainers are summoned by Mewtwo to have a battle with it, but they soon discover that they're only being invited so Mewtwo can clone their Pokemon for it's own purposes. Ash then tries to find a way to stop Mewtwo's plot before it can be carried out. 
(Source: Anime News Network)

A young boy named Satoshi embarks on a journey to become a "Pokémon Master" with his first Pokémon, Pikachu. Joining him on his travels are Takeshi, a girl-obsessed Rock Pokemon Trainer, and Kasumi, a tomboyish Water Pokémon Trainer who may have a crush on him. Satoshi and Co. end up traveling through various regions, including Kanto, the Orange Islands, and Johto, and then enter the Pokémon League competitions there. Along the way, they run into many confrontations with Musashi, Kojirou, and Nyarth, a trio of Pokémon thieves who are apart of an evil organization called "Team Rocket". But everytime Team Rocket try to do their evil deeds, they fail thanks to Satoshi and his Pokémon. 
(Source: Anime News Network)

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