In response to The Biggest, Most Awful, Most Tragic Event in Human History, an organization called Future Foundation was created to combat the chaos still present even after the death of The Mastermind. Misaki Asano is a new recruit, working as a special investigator for the 6th Division's Special Case Bureau—a branch dedicated to only the most bizarre and challenging murder cases. Alongside her partner, Takumi Hijirihara, they aim to combat despair one case at a time. 
 
Though, perhaps their most challenging case is that of the mysterious Killer Killer, a bizarre serial killer who chooses to target other murderers. 
 
(Source: Danganronpa Wiki)

Makoto Naegi, the Ultimate Hope who defeated the Ultimate Despair, Junko Enoshima, is under suspicion of treason against the Future Foundation for harboring the Remnants of Despair who carried on her will. As top members of the Future Foundation, including Makoto's former classmates Kyoko Kirigiri, Aoi Asahina, and Yasuhiro Hagakure, are brought together to decide on Makoto's punishment, they are all imprisoned by Monokuma, who forces everyone to participate in a final killing game. They must try to find the traitor among them who will kill them in their sleep, while also trying to avoid being mortally poisoned by personalised forbidden actions. Thrust into a game where no one can trust each other, Makoto's ideals of hope are pushed to their very limits. 
 
(Source: IMDB, edited) 
 
Aired alongside of Danganronpa 3: Zetsubou-hen, with Mirai-hen starting first.

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