Saya is a seemingly normal girl living with her father in a shrine. During the day she goes to school and spends time with her friends at a local cafe. But when night falls Saya is called upon to protect her village from strange monsters. 
(Source: Anime News Network)

Despite the use of the Youth Ordinance Bill to enforce curfews for minors and regulate the use of the internet, young people continue to fight for their own freedom through underground methods. One such group calls themselves SIRRUT. They have decided to take on Fumito Nanahara, a man who has great influence on the political world, and basically controls Tokyo with an iron fist. While using the internet as a weapon to discover more information about Fumito, they learn about "Tower", the secret organization behind Fumito which engages in human experimentation. 
When members of Surat attempt to set up an ambush in the subway to expose the truth behind "Tower", mysterious creatures suddenly appear and attack the passengers. During this crisis, Saya appears - a young girl who uses a Japanese blade to slay the Old Ones. The same Saya who lost everything dear to her in that horrifying incident in Ukishima Province. What sort of "experiment" is Fumito and "Tower" trying to conduct using the Old Ones? And can Saya finally deliver vengeance to Fumito? 
Now, the final battle begins... 
(Source: Official site)

A series of short specials aired on the official website prior to the movie release. It consists of an explanation about the anime from the perspective of the twin characters, Motoe Nono and Motoe Nene. 
An additional episode was aired at the Clamp Festival 2012. It was later included in Blood-C: The Last Dark Limited Edition BD and DVD.

Saya Otonashi, a seemingly normal high school student, suffers from amnesia and she can't remember the past year of her life. One day, after a man appears and gives her a katana sword, her destiny begins to be revealed. 
 
Soon she finds herself fighting the latest threat to humanity - Chiropteran monsters, ravenous immortal creatures that can change their form, disguising themselves as human beings. They feed off blood and hide themselves within the human world. An organization known as the Red Shield has been waging a private war to wipe them out and now the struggle has grown. Saya's journey for the truth has begun. 
 
(Source: Sony Pictures Home Entertainment)

Teropterids are evil beasts which pose as humans and live only to drink human blood. Fortunately for the human world there are groups dedicated to destroying them. A brooding and mysterious girl named Saya is the best teropterid slayer there is, and now, in 1960's Japan, she is sent to a U. S. army base which may be infested... 
(Source: Anime News Network)

Watanuki Kimihiro can see spirits and other assorted supernatural creatures, which is quite a bothersome ability he strongly dislikes. On the way home one day, while plagued by some spirits, he is inexplicably compelled to enter a strange house. There, he encounters Yuuko, a mysterious woman who claims to be able to rid him of the ability to see and attract the troublesome creatures – for a price. She demands for him to work at her "store" that grants wishes to people, and thus begins Watanuki's adventures through weird and wonderful events.


Ukishima Shrine is located in an old, picturesque lakeside town. Shrine maiden Kisaragi Saya lives there along with her father, Tadayoshi. By day, she lives the life of a normal high school student at Sanbara Academy. By night, she hunts the Old Ones. Possessing supernatural physical prowess, the Old Ones prey on humans, and only Saya has the ability to defeat them. 
(Source: AniDB)

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