She hunts chiropterans using a katana. It is implied that she is the last remaining vampire and is called &quot;the only remaining original.&quot; Saya has no weakness to sunlight but it is unknown if she has any of the other vulnerabilities of normal vampires. However, she becomes distressed when she encounters religious people and angry when people mention God in her presence. Saya displays superhuman senses and strength, as well as cunning, resourcefulness, and skill. 

The manga series suggests she was a human-vampire hybrid.

Teropterids are evil beasts which pose as humans and live only to drink human blood. Fortunately for the human world there are groups dedicated to destroying them. A brooding and mysterious girl named Saya is the best teropterid slayer there is, and now, in 1960's Japan, she is sent to a U. S. army base which may be infested... <br><br>
(Source: Anime News Network)

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Blood: The Last Vampire 2002 is a powerfully drawn original graphic novel narrative based on characters and situations from the 2001 anime Blood: The Last Vampire, once the fastest-selling title in the history of Manga Entertainment. Taken from a concept developed by Ghost in the Shell's Mamoru Oshii, one of the 21st century's hottest young comics artists, the violent, erotic Benkyo Tamaoki, updates the Vietnam War-era anime story to present-day, 2002 Japan. The immortal Saya returns - a generation later, but still clad in her trademark sailor suit and armed with ancient samurai sword - continuing her unholy war against the vampiric Chiropterans. Infiltrating a gang-ridden high school, Saya more than suspects the brutal set known as "ORGE" is just the latest mask of her blood-thirsty prey.
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(Source: Viz Media)

This novel is set in Japan in the late 1960s, where the youth are organizing a violent uprising against the government.  Part of this revolt is the politically active student, Rei, whose fate is one day, coincidentally, bound to a mysterious girl, Saya.  An exciting criminal case, and a voyage into the discovery of vampirism, takes its course.