Based on a Chinese web comedy manga. 
 
Shi Miao simply cannot stand her lazy, stupid, and unreliable elder brother Shi Fen, who is one year above her at the same high school. Though the two siblings can only depend on each other, Shi Miao's violent tendencies combined with Shi Fen's knack for causing trouble cause them to fight constantly. And so, Shi Miao can only hope that someone might take her brother away—even though, when push comes to shove, Shi Fen always tries to do what he believes is best for his cute younger sister. 
 
Note: Airing dates reflect the original airing and premiere dates in China, where it aired earlier than it did in Japan.

What's your brother like? To Miao, her brother Fen is someone who would tease her and make her explode 100 times a day; not a peaceful day as the two are fighting every single minute. However, when troubles come, Fen will become a caring, loving brother who protects his little sister at all cost.


The second season of Ani ni Tsukeru Kusuri wa Nai!. 
 
As always, Shi Miao is tired of her brother's ridiculous antics, and Shi Fen can only hope to escape the clutches of his violent sister. With their friends and classmates in tow, the two continue their dysfunctional relationship as reluctant but devoted siblings. 
 
Note: Airing dates reflect the original airing and premiere dates in China, where it aired earlier than it did in Japan.

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