In the 19th century, Genoa (Italy), 9-year-old Marco must face separation from his mother Anna, who leaves for work in Argentina to escape heavy taxes and a deep economic depression. Remaining at home with his father-a doctor at the hospital for the poor-Marco cannot help but miss his mother. When Anna suddenly stops writing to them, Marco becomes anxious about her and decides to travel all the way to Argentina by himself. Marco sets out a long and arduous adventure of over 10,000 miles. All he carries with him is love, courage, friendship and a longing to see his mother again. The story will take you on an exciting journey across the Atlantic, the Andes, and the spiritual border as we watch Marco come of age. <br><br>
(Source: AnimeNfo) 

Based on a short section of the novel Cuore by the Italian Edmondo de Amicis, Marco is a young boy living in Genoa, Italy, together with his father Pietro. But the family is not complete, for Marco`s mother left for Argentina around a year earlier in order to find work. Letters from her arrive regularly until one day they suddenly stop. Worry for his mother and what might have happened to her overcomes the young boy. Marco thus decides to embark upon a journey to Argentina in the hope of being reunited with his mother. At first, Pietro is opposed to Marco`s plan, but moved by his son`s enthusiasm, he eventually allows the boy to go. So begins Marco`s long journey of the heart. Marco encounters many people throughout his travels, and finds maturity and self-acceptance as a result of his experiences.<br><br>
(Source: Nippon Animation)

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