The gang is traveling along when they find a girl in need. Of course, they all can't resist going after her. This girl isn't all that she seems... her motive or her "humanity".... and soon the whole gang has Sanzo's past on their hands and one certain young boy who can keep a grudge for decades...
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(Source: Anime News Network)

Many years ago, humans and demons lived in harmony. But that unity ended when demons started attacking humans and plotted a mission to unleash Gyumao - an evil demon imprisoned for thousands of years. Now, Genjo Sanzo, a rogue priest, must team up with three demons - Sha Gojyo, Son Goku, and Cho Hakkai - and embark on a perilous journey to the west to stop these demons from resurrecting Gyumao and restore the balance between humans and demons on Earth.
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(Source: Anime News Network)

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