It seems that when Lum was born, a postal screwup resulted in a witchy friend of the family not getting an invitation to the celebration. The witch put a curse on Lum, that she would never be happy with her True Love. 
In the present, a new Amusement Park has been built in Tomobiki, and opening day finds the whole gang sampling its pleasures. At a magic show, however, Ataru gets turned into a large pink hippo-potamus, FOR REAL! 
When Lum attempts to track down the magician that transformed her Darling, things start to get very weird, very fast! 
(Source: AniDB)

Urusei Yatsura concerns the tempestuous relationship between two focal characters: Ataru Moroboshi who is possibly the most unfaithful, unlucky and lecherous idiot to have ever been born, and there's Lum, a tigerskin-bikini clad alien package of sex appeal, jealousy and electricity who's fallen for him. The series chronicles the misadventures of these two stubborn teenagers along with a veritable entourage of weird characters. Among these characters is the richest boy on the planet, a superhuman schoolgirl, a fire-breathing baby, a powerful priestess/school nurse, a cute and psychotic alien vixen with a split personality, a gender-bending martial artist, an alien biker chick, an ice queen of Neptune, a deranged monk, a giant ghost cat and hundreds of other lunatic personalities; aliens, humans and inhumans alike interract in endless hysteria in a town named Tomobiki.

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