On a forbidden hospital ward, the head doctor performs madly erotic experiments, stripping the nursing staff of their uniforms, inhibitions and self-control... until even he is shocked by what he uncovers!

An elite doctor Kuwahara couldnt forget his thought toward Nanase Ren, whom he had loved in his youth. Then he changed the hospital to work one after another to look for her, and finally he met her again at the St. Cattleya Hospital. However, her attitude was remote and his love couldnt be fulfilled. To make the matter worse, he received photograph on which Ren was molested. Ren had been turned into a lewd woman by Hirasaka by the woman body experiment when she was at the St. Julianna Hospital. He was disappointed and he lost his mind. Kazama Mana who was a nurse of the gynecology and obstetrics section, loved Kuwahara, and she resembled Ren. Taking advantage of her thoughts, Kuwahara raped her and deprived her virginity shouting the name of Ren. 
(Source: AnimeNfo)

This will appear to be a very disturbing animation to most. Designs by Murakami Teruaki, published by Soft by Demand (Anime), and based on the eroge by M no Violet. 
(Source: Bakunyuu) 
Note: There are 2 Nanase Ren OVAs produced totally different studios, but both feature the same character. The other one is the "Kranke Nanase Ren" (夜勤病棟　Kranke　七瀬恋) bit, which is a special for Yakin Byouto 
(Source: AniDB)

A side story from the original: Ai wishes to be a real woman, after thinking that she had dreamed her sister doing with the doctor. On the other hand, Ryuji Hirasaka wants to have his pervert experiments trial on Hikaru. Instead, the doctor become a savior to Hikaru &amp; Ai for his new invention having both sisters doing it to one another and Ai thought that it as a dream... The last episode ends as the doctor and his newly wedded bride nurse, Ren, went exile to a village to continue his medical practice... and of course his experiment only on his bride.
 
(Source: Anime News Network)

Two recap episodes of the original Yakin Byoutou OVA also known as episodes 5.5 and 10.5.

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